Profound Hypothermia-Induced Platelet Dysfunction during Heparinized Cardiopulmonary Bypass | ||||||
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There is an impression among cardiothoracic
surgeons that the technique of profound hypothermic circulatory
arrest (PHCA) is associated with an increased bleeding tendency
compared to conventional bypass surgery. In addition to the recognized
factors contributing to the hemorrhagic tendency seen in moderate
hypothermic cardiopulmonary bypass (CPB), it is likely that the
lower temperature utilized in PHCA may exacerbate platelet dysfunction.
In this report, platelet counts and functions at the same cardiopulmonary
bypass time were compared in human PHCA surgery (hypothermia
group, n=16) and moderate hypothermic cardiopulmonary
bypass surgery (control group, n=20). Mean platelet count
corrected by hematocrit in the hypothermia group at 2 h of CPB
was significantly lower than in the control group (3.7×104µl
vs. 11.4×104/µl, p<0.0001). In the hypothermia
group, there were significant increases in the percentage of
GMP-140 (P-selectin)-positive platelets (11.8% vs. 8.3%, p=0.0091)
at 1 h of CPB, and also in microparticles (24.8% vs. 10.5%, p<0.0001)
and aggregated platelets (3.4% vs. 1.4%, p=0.0058) at
2h of CPB. Profound hypothermic circulatory arrest used in surgery
for aortic arch aneurysm or dissection may cause irreversible
platelet dysfunction and contribute to hemorrhagic tendency during
the surgery. To minimize platelet dysfunction during CPB, the
lowest blood temperature should be maintained above 15°C. Jpn. J. Cardiovasc. Surg. 33: 147-151 (2004) |
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Acute Aortic Dissection Combined with Obstructive Sleep Apnea Syndrome | ||||||
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Obstructive sleep apnea syndrome
(OSAS) has symptoms such as severe snoring, apneic attack, and
daytime hypersomnia due to repeated obstruction of the upper
respiratory tract during sleep. The mortality rate due to cardiovascular
complications in severe OSAS. We reported 5 cases of OSAS among
the acute aortic dissection cases we treated. They were 2 cases
of DeBakeyI (cases 1, 2) and 3 cases of IIIb (cases 3, 4, 5).
Organ ischemia was recognized in 4 among 5 cases of dissection
combined with OSAS. There was 1 case of renal ischemia (case
1), 2 cases of limb ischemia (cases 3, 4), 1 case of visceral
and spinal ischemia (case 5). Case 4 was IIIb type dissection
with severely compressed true lumen and limb ischemia. The false
lumen occluded by combining antihypertensive therapy and continuous
positive airway pressure used to OSAS. Case 5 also had a severely
compressed true lumen, and visceral ischemia 4 days after the
onset. Angiography showed a severly compressed orifice of the
true lumen of the celiac artery and superior mesentric artery
due to the occluded false lumen. We placed a stent into the orifice
of celiac artery transluminally and then patient recovered. There
were many dangerous situations such as organ ischemia, and severely
compressed true lumen among the cases of dissection combined
with OSAS. Marked changes of intrathoracic pressure in apneic
attacks may place stress on the thoracic aorta. Jpn. J. Cardiovasc. Surg. 33: 152-157 (2004) |
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Simultaneous Axillo-Axillary Crossover Bypass Grafting and Off-Pump CABG Using Bilateral Internal Thoracic Arteries in a Patient with Severe Atherosclerosis in Both the Ascending Aorta and Proximal Left Subclavian Artery | ||||||
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Combined surgery for left subclavian
artery revascularization and CABG was performed in a 74-year-old
man with diabetes mellitus. The preoperative coronary angiogram
showed critical stenoses in all three major branches, and arteriography
revealed obstruction at the left proximal subclavian artery.
Severe atherosclerotic calcification was acknowledged circumferentially
in the ascending aorta and in the aortic arch. For this patient
axillo-axillary crossover bypass grafting was performed first
using and expanded PTFE graft, followed subsequently by off-pump
CABG using all in situ grafts (right internal thoracic
artery-left anterior descending artery (RITA-LAD), left internal
thoracic artery-diagonal branch (LITA-diagonal branch), gastro-epiploic
artery-right coronary artery (GEA-RCA)). Postoperative recovery
was smooth, with disappearance of significant pressure difference
between both arms (preoperatively, 46mmHg). An angiogram on the
7th postoperative day showed a widely patent axillo-axillary
bypass graft along with good flow of all three coronary grafts,
in which LITA was visualized well through the axillo-axillary
bypass graft. For complex atherosclerotic disease of the proximal
aorta and incipient portion of neck vessels associated with severe
coronary sclerosis, this technique is a suitable option. Jpn. J. Cardiovasc. Surg. 33: 158-161 (2004) |
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Abdominal Aortic Aneurysm Accompanied by Aortic Dissection | |||||||||
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Three cases of aortic dissection
involving abdominal aortic aneurysms are reported. Two of the
3 cases died from intestinal necrosis. In one of them, the abdominal
aortic aneurysm ruptured following aortic dissection. Fenestration
was not performed at the proximal anastomosis in the operation,
and it is thought that this resulted in occurrence of intestinal
necrosis due to superior mesenteric artery obstruction. In the
other non-survivor, aortic fenestration and graft replacement
were performed. However, he died from descending―sigmoid colon
necrosis due to internal iliac artery obstruction. An autopsy
demonstrated no problem that with the graft anastomosis. The
successful case of aortic fenestration and graft replacement
had no postoperative complications. Since the aortic wall is
fragile in acute aortic dissection, it is advisable that operation
be conducted 1 month after the onset except in cases of aortic
rupture and malperfusion syndrome. Fenestration, which is usually
safe in chronic dissection, should be performed and it is desirable
to fenestrate the aortic wall if possible even in acute dissection. Jpn. J. Cardiovasc. Surg. 33: 162-165 (2004) |
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A Case of Postinfarction Left Ventricular Free Wall Rupture in an Elderly Patient | |||||||||
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An 85-year-old man was admitted
complaining of chest pain. The ECG showed ST depression in leads
II, III, aVF, V3~V6
and Q wave in leads I, aVL with elevation
in ST segments. An emergency coronary angiography revealed 75%
stenosis in the left main trunk, 75-90% stenosis in the left
anterior descending artery, total occlusion in the acute marginal
branch, 75% stenosis in the left circumflex artery, and 75% stenosis
in the right coronary artery. He was treated medically, because
he was old and his hemodynamics were stable. About 39h later,
he lost consciousness suddenly and was shown to have cardiogenic
shock. Echocardiogram revealed pericardial effusion. Percutaneous
drainage was performed, resulting in improved blood pressure
and level of consciousness. He was transferred to Okaya Enrei
Hospital and received emergency surgery for subacute LVFWR. A
sutureless repair and coronary bypass was performed under cardiopulmonary
bypass and cardiac arrest. He experienced no major complication
and was discharged 40 days after surgery. It is concluded that
the sutureless technique allowed for a shorter operation time
and concomitant coronary bypass successfully prevented pseudo-aneurysm
and improved cardiac function. A higher quality operation is
possible by using a combination of on-pump, cardiac arrest, coronary
bypass and left ventricle repair with the sutureless technique
in such cases in which treatment is needed for cardiac arrest
as in the above example. This method contributed to an improved
prognosis. Jpn. J. Cardiovasc. Surg. 33: 166-170 (2004) |
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A Case of Spontaneous Resolution of Systolic Anterior Motion after Mitral Repair | ||||||
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A 70-year-old patient underwent
modified maze procedure and mitral repair including quadrangular
resection, annular plication (Reed procedure), and flexible ring
annuloplasty with Cosgrove ring. Systolic anterior motion (SAM)
of the anterior mitral leaflet and mild mitral regurgitation
was observed on weaning from cardiopulmonary bypass. The patient
was medically treated, and postoperative echocardiography revealed
disappearance of the SAM 11 days after surgery. In addition to
the surgical condition of rather excessive annular plication
and small ring, transient conditions including inotropic support,
insufficient volume under diastolic dysfunction of left ventricle,
and loss of atrial contraction were thought to be the causes
of SAM. Jpn. J. Cardiovasc. Surg. 33: 171-174 (2004) |
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A Case of Total Anomalous Pulmonary Venous Connection with Two Vertical Veins Draining to the Infracardiac Level | |||
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Infracardiac type total anomalous
pulmonary venous connection (TAPVC) was diagnosed in a 1-day-old
boy. We performed emergency total correction on day 1 and found
2 vertical veins draining to the infracardiac level separately.
Each vertical vein was rerouted to the left atrium. On the first
postoperative day, an extracorporeal membrane oxygenation was
required because of respiratory failure. He died due to cerebral
hemorrhage on the 5th day after the operation. Macroscopic findings
showed the right sided vertical vein draining to the IVC, and
the left sided one to the confluence of the hepatic vein and
ductus venosus. Microscopic findings of the lung revealed markedly
dilated lymphatics which was suspected as the cause of respiratory
failure. Although cases with 2 separate vertical veins are very
rare, the precise anatomy of PV return has to be checked intraoperatively
when the preoperative identification has not been established. Jpn. J. Cardiovasc. Surg. 33: 175-177 (2004) |
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Patch Graft Aortoplasty for Repair of Chronic Aortic Dissection | |||
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A 72-year-old woman was admitted
as an emergency case to our hospital because of chest oppression.
She had a history of admission due to the same symptoms about
9 months previously. Her chest computed tomography showed a dissection
of the ascending aorta (DeBakey type II). We suspected an acute
aortic dissection and an emergency operation with CPB was performed.
The ascending aorta was markedly enlarged, but the dissected
adventitia did not appear weakened. Moreover, there was no bloody
pericardial effusion which is specific to acute aortic dissection.
When the pseudo-lumen was exposed, a firm intimal flap and single
entry hole were recognized. The chronic phase of aortic dissection
was finally diagnosed. Then the dissected adventitia and intimal
flap were removed and a patch graft aortoplasty with a tailored
26mm gelatin-impregnated knitted Dacron vascular graft was employed
because the residual aortic wall was normal in size and consisting.
Her postoperative course was uneventful and there was no evidence
of recurrence of aortic dissection or enlargement 2 years after
the operation. We conclude that patch aortoplasty for repair
of chronic aortic dissection can be effective when the range
of dissection is restricted and te residual aortic wall is normal. Jpn. J. Cardiovasc. Surg. 33: 178-181 (2004) |
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Aortic Valve Replacement Following Infectious Endocarditis Requiring Re-Operation Three Times | ||||||
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A 47-year-old man with active aortic
valve endocarditis underwent direct closure of a paraannular
abscess and valve replacement. Methicillin-resistant Staphylococcus
aureus was isolated from his blood culture preoperatively.
Because of a postoperative paravalvular leak (PVL) and an echo-free
space suggesting a residual cavity, he was reoperated for patch
closure of the aneurysm and prosthetic valve replacement. However,
the PVL and paraannular cavity were still observed after the
2nd surgery. At the 3rd operation, prosthetic valve detachment
along one fourth of its circumference was confirmed, and the
cavity was fully opened. A patch was used to cover the pseudoaneurysm
and was placed under the orifice of the left coronary artery.
This patch repair of the cavity was accomplished, followed by
prosthetic valve replacement in situ. Trivial PVL was identified
after the operation, and a diagnosis of intravascular mechanical
hemolysis was made. Clinical examination revealed partial detachment
of the prosthetic valve resulting in a significant PVL and paraannular
pseudoaneurysm. Because of unremitting hemolysis and the increased
PVL, the patient underwent a 4th repair. Inspection showed that
the prosthetic valve was partially detached and the defect was
opened at the upper edge. The orifice of the aneurysmal was covered,
and valve replacement was performed in the supraannular position
using 3 U-stays, which were passed through both the aortic wall
and the patch, followed by ascending aortic graft replacement.
In the case of aortic valve endocarditis with paraannular involvement,
radical debridement and complete reconstruction of the left ventriculoaortic
discontinuity without tension are required. Jpn. J. Cardiovasc. Surg. 33: 182-184 (2004) |
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A Case of Pseudoaneurysm of the Ascending Aorta Found at Onset of Acute Aortic Dissection after Aortic Valve Replacement | ||||||
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A pseudoaneurysm of the ascending
aorta is a complication found in aortic valve surgery. A 66-year-old
man who had a previous history of aortic valve replacement due
to infectious endocarditis was admitted to our hospital suffering
from chest pain. Follow-up chest X-ray and transthoracic echocardiogram
had revealed no findings of pseudoaneurysm during the intervening
period. At admission, computed tomographic scan and transesophageal
echocardiogram each showed a Type A acute aortic dissection and
a pseudoaneurysm of the ascending aorta. Under cardiopulmonary
bypass and deep hypothermic circulatory arrest, an ascending
aortic graft replacement was carried out uneventfully. The patient
is well 14 months postoperatively. Postoperative examinations
following aortic surgery should be performed not only from the
view point of cardiac function, but also from that of a pseudoaneurysm. Jpn. J. Cardiovasc. Surg. 33: 185-188 (2004) |
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A Case Report of Delayed-Onset Lower Spinal Cord Injury after Replacement of the Aortic Arch and the Descending Thoracic Aorta Using a Stented Elephant Trunk | ||||||
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Higher incidence of spinal cord injury has been reported in total aortic arch replacement using a stented elephant trunk compared with the conventional one, perhaps due to embolism of atheromatous plaque to the spinal cord arteries. We report a case with delayed-onset lower spinal cord injury after replacement of the aortic arch and the descending thoracic aorta using a stented elephant trunk. A 69-year-old man who had a history of abdominal aortic aneurysm repair using a Y-graft and untreated Crawford’s type II thoracoabdominal aortic aneurysm underwent replacement of the aortic arch and the descending thoracic aorta using a stented elephant trunk. He developed weakness of the lower extremities 4 days after the operation. Since a preoperative computed tomography demonstrated thrombus and atheroma in the aneurysm, atheromatous plaque that can cause embolization of the spinal cord arteries was suspected to be responsible for spinal cord injury. As this technique is mostly applied to patients with severe atheromatous aortic disease, embolization of the intercostal arteries or other main branches caused by manipulation of a stent graft must be avoided. Jpn. J. Cardiovasc. Surg. 33: 189-192 (2004) |
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A Case of Endoventricular Circular Patch Repair (Dor Operation) and CABG for Pseudo-False Ventricular Aneurysm of Left Ventricular Wall | |||||||||
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Aneurysms of the inferior left ventricular
wall comprise only a small fraction of all aneurysms that have
been reported in surgical series. Pseudo-false ventricular aneurysm
is very rare and communicates with the left ventricule through
a small orifice, and its wall contains myocardial tissue, unlike
false ventricular aneurysm. A 53-year-old man was admitted to
our hospital with chest pain. Echocardiography revealed left
ventricular aneurysm, and the coronary arteriography subsequently
revealed a complete occlusion of right coronary #2 and 75% and
90% stenosis of left anterior descending artery #7 and#8, respectively.
Left ventriculography revealed an aneurysm of the inferior left
ventricular wall, which communicated with the left ventricle
through a small orifice and exhibited contraction. Surgical repair
was indicated. Endoventricular circular patch repair (Dor operation)
of the aneurysm of the inferior left ventricular wall and coronary
artery bypass grafting to the left anterior descending artery
and the right coronary artery were simultaneously performed under
cardiopulmonary bypass with moderate hypothermia. The postoperative
course was uneventful and the patient was discharged on the 22th
day after surgery. Pseudo-false ventricular aneurysm of the inferior
left ventricular wall was diagnosed by pathologic examination. Jpn. J. Cardiovasc. Surg. 33: 193-196 (2004) |
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Successful Management of Infected Superficial Femoral Aneurysm Caused by Citrobacter koseri | ||||||
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A 77-year-old man with diabetes
mellitus and hypertension presented with acute onset of pain
and swelling of the right thigh. Physical examination showed
a pulsatile mass in the mid-portion of the right thigh. Computed
tomography revealed the presence of a 7-cm diameter aneurysm
at superficial femoral artery with gas shadow around the aneurysmal
wall. A diagnosis of infected superficial femoral aneurysm was
made and emergency surgery was undertaken. The total resection
of the aneurysmal wall, debridement of necrotic tissues including
part of sartorius and quadriceps muscles were done. Femoro-popliteal
bypass through subcutaneous route using a 6-mm diameter Dacron
prosthesis was used as the mean of vascular reconstruction procedure.
Citrobacter koseri was cultured from the infected aneurysmal
wall. The antibiotic treatment was continued for total of 2 weeks.
Although additional debridement was required, the patient was
amkulabony when discharged on the 37th postoperative day. Jpn. J. Cardiovasc. Surg. 33: 197-200 (2004) |
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Successful Revascularization Using Cardiopulmonary Bypass in a Case of Angina Abdominalis due to Acute Superior Mesenteric Arterial Embolism | |||
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An 89-year-old man with a past history
of paroxysmal atrial fibrillation was urgently admitted to our
hospital because of sudden-onset pain in the left forearm. The
pulse of the left brachial artery had disappeared. Angiography
demonstrated left brachial artery occlusion due to a thrombus.
The day after an emergency thrombectomy, abdominal pain occurred
after eating. Enhanced computed tomography and aortography revealed
that the superior mesenteric artery (SMA) was occluded with collateral
circulation from the inferior mesenteric artery (IMA). Under
a diagnosis of angina abdominalis, the bypass procedure, using
a saphenous vein graft (SVG) from the abdominal aorta to the
SMA, was carried out under the support of cardiopulmonary bypass.
To maintain antegrade alignment of the SVG, the SVG was anastomosed
proximally to the infrarenal abdominal aorta. Severe atherosclerotic
changes were observed in the main trunk of the SMA. However,
no intestinal necrosis occurred because of the well-developed
collateral flow from the IMA. The mechanism of angina abdominalis
is probably due to thromboembolism in the SMA which had preexisting
stenotic organic lesions. Jpn. J. Cardiovasc. Surg. 33: 201-204 (2004) |
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Emergency Reoperation for Vein Graft Rupture Caused by PCI Failure | |||
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A 68-year-old woman on chronic hemodialysis
was admitted to our hospital for further evaluation because of
recurrent angina 14 months after coronary bypass surgery (left
internal thoracic artery-left anterior descending artery (LITA-LAD),
gastro-epiploic artery-4 posterior descending artery (GEA-4PD),
saphenous vein graft-#9-#14 sequential (SVG-#9-#14 sequential)).
On coronary angiography, a localized 90% stenosis of the vein
graft was present at the anastomosis with the diagonal branch
of the native coronary artery. Although the lesion was relieved
with a 5mm balloon catheter inflated to 14 atmospheres, contrast
injection demonstrated extravasation of dye into the pericardial
space, indicating vein graft rupture. Repositioning the inflated
balloon across the rupture site for hemostasis was unsuccessful,
and the patient was transferred to the operating room. Emergency
reoperation was accomplished through a left lateral thoracotomy
without cardiopulmonary bypass. Although hemorrhage was not noted
at the rupture site, the vein graft was ligated at the proximal
and distal portions of the rupture, followed by a new vein graft
bypass. Postoperative cardiac catheterization clearly demonstrated
the patent graft. Although localized hypokinesis was observed
in the lateral wall on postoperative echocardiography, the left
ventricular ejection fraction was 67%, her activity level was
good, and she had no angina. Jpn. J. Cardiovasc. Surg. 33:205-207 (2004) |
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A Case of Severe Aortic Stenosis Accompanied by Porcelain Aorta Treated with an Apicoaortic Valved Conduit | ||||||
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The patient was a 70-year-old woman
with severe aortic stenosis and familial hyperlipidemia which
was diagnosed in 1994. The patient was admitted as an emergency
case due to syncope in 2002. According to ultrasound cardiography
(UCG), the pressure gradient of the aortic valve was 120.7mmHg,
and the diameter of the aortic valve annulus was 16.7mm. Computed
tomography showed porcelain aorta from the annulus of aortic
valve to the ascending aorta. On cardiac catheterization, the
pressure gradient was 96mmHg, AVA was 0.4cm2, and the ejection
fraction was 38.7%. Since these findings suggested that conventional
AVR was difficult, thoracotomy was performed at the left 5th
intercostal level, and apicoaortic valved conduit (valved graft:
SJM19HP, Intergard 22mm+Medtronic apical LV connector) was implanted.
Postoperative cine MRI showed that most of the cardiac output
(87%, 3.29l/min) flowed
through the conduit, with the flow via the aortic valve accounting
for 13%, 0.51l/min. This surgical procedure can be an
effective alternative when conventional AVR is difficult. Jpn. J. Cardiovasc. Surg. 33: 208-212 (2004) |
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A Modified Procedure Using Branched Graft as Inflow for Leg Revascularization in a Case of Acute Type A Aortic Dissection Complicated with Leg Ischemia | |||
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A 32-year-old man with severe back
pain and cold, pulseless bilateral lower extremities was admitted.
Enhanced CT scan revealed acute type A aortic dissection and
the true lumen was severely compressed or occluded at the level
of the abdominal aorta. Emergency simultaneous graft replacement
of the ascending aorta and aortic arch was performed under deep
hypothermic circulatory arrest, antegrade selective cerebral
perfusion in addition to the elephant trunk technique. Although
distal anastomosis was constructed only to the true lumen, leg
ischemia persisted. Therefore, a new modified procedure applying
a branched graft used for antegrade systemic perfusion as inflow
and conventional axillo-bifemoral bypass graft was anastomosed
to restore adequate circulation to the lower extremities. In
the treatment of acute type A aortic dissection complicated with
leg ischemia, the modified technique we employed is a simple
and feasible method for leg revascularization in cases in which
malperfusion to the leg persists in spite of complete of aortic
repair. Jpn. J. Cardiovasc. Surg. 33: 213-215 (2004) |
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Successful Surgical Repair of Left Main Coronary Artery Total Occlusion with Aortitis Syndrome | |||||||||
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We report the successful repair of left main coronary artery obstruction with aortitis syndrome. She was a 39-year-old woman and was admitted to Saiseikai Kumamoto Hospital because of angina pectoris. Her bilateral radial artery pulsation was not palpable. Total occlusion of the left main coronary artery (LMT) and bilateral subclavian artery was detected by angiography. Patch enlargement of the LMT was performed using a Distaflo (Impra Carbon PTFE) graft. Postoperative coronary angiography showed an adequate LMT diameter and sufficient blood flow. Jpn. J. Cardiovasc. Surg. 33: 216-219 (2004) |
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Successful Surgical Treatment of Ruptured Abdominal Aortic Aneurysm Following Stanford Type B Acute Aortic Dissection | ||||||
|
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A 72-year-old man presented with
back pain and 3 days after admission, chest and abdominal CT
scanning revealed the existence of infrarenal abdominal aortic
aneurysm with Stanford type B acute aortic dissection and hemorrhage
in the retroperitoneal space. The maximum diameter of the abdominal
aortic aneurysm was 60mm. After treating with anti-hypertensive
therapy under restrictive observation because of the patient's
stable general condition, surgery was performed 45days after
admission. The dissection extended into the abdominal aortic
aneurysm and all visceral arteries branched from the true lumen.
The presence of thrombus in the preperitoneal space suggested
a ruptured abdominal aortic aneurysm. Abdominal aortic aneurysm
was replaced with a Y shaped graft and proximal anastomoses was
performed with fenestration to prevent rupture of the proximal
dissecting aorta. We report a rare case of ruptured abdominal
aortic aneurysm following Stanford type B acute aortic dissection,
which was operated on in the chronic stage. The patient is doing
well. Jpn. J. Cardiovasc. Surg. 33: 220-223 (2004) |
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Redo Off-Pump Coronary Artery Bypass Grafting through Left Thoracotomy Using the Aortic Connector for Proximal Graft Anastomosis on the Descending Aorta | |||
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A 76-year-old man who had undergone primary coronary operation through a median sternotomy 9 years previously presented with recurrent angina. Preoperative angiography revealed 90% stenosis of the circumflex coronary artery and left subclavian artery. Two saphenous vein grafts (SVG) placed in the previous operation were patent. Redo off-pump CABG was performed through a left thoracotomy approach. The proximal end of the new SVG was connected to the descending thoracic aorta using the St. Jude Medical aortic connector system. The distal anastomosis to the obtuse marginal branch was performed on a beating heart. The postoperative course was uneventful. This case suggested that, in cases requiring the proximal graft anastomosis on the descending aorta, the application of the aortic connector system can be a useful strategy, helping to facilitate the proximal anastomosis and avoid complications associated with the aortic partial-clamping on the descending aorta. Jpn. J. Cardiovasc. Surg. 33: 224-226 (2004) |
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